RF9检测

RF9

生物活性靶点体外研究体内研究 用途与合成方法 MSDS RF9价格(试剂级) 上下游产品信息中文名称中文同义词英文名称英文同义词CAS号分子式分子量EINECS号相关类别Mol文件结构式

RF9

神经肽FF受体拮抗剂RF9;化合物 T16738;N2-(金刚烷-1-基羰基)-L-精氨酰基-L-苯丙氨酰胺;2-金刚烷羰基-精氨酸-苯丙氨酸-NH2三氟乙酸酯(RF 9 TFA);RF9|||RF-9

2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE

2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE;2-Adamantanecarbonyl-Arg-Phe-NH2;RF 9;1-Adamantanecarbonyl-Arg-Phe-NH2;1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt;RF9 trifluoroacetate salt;RD9;L-Phenylalaninamide, N2-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-

876310-60-0

C26H38N6O3

482.62

标准品;目录肽

876310-60-0.mol

RF9 性质

密度储存条件溶解度酸度系数(pKa)形态颜色

1.42±0.1 g/cm3(Predicted)

Store at -20°C

H2O：可溶，20mg/mL

14.53±0.20(Predicted)

固体

白色

RF9 用途与合成方法

生物活性RF9 是一种有效且有选择性的神经肽 FF 受体 (Neuropeptide FF receptor) 拮抗剂 ，对于 hNPFF1R 和 hNPFF2R 的 Ki 值分别为 58 和 7 nM。靶点

hNPFF1R 58 nM (Ki)

hNPFF2R 75 nM (Ki)

体外研究

RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells.

体内研究

RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9.

Animal Model:	Rats.
Dosage:	0.1 mg/kg.
Administration:	S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats.
Result:	Opposed to delaye heroin-induced hyperalgesia and associated tolerance.