马来酸甲麦角新碱检测

马来酸甲麦角新碱

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 马来酸甲麦角新碱价格(试剂级) 上下游产品信息中文名称中文同义词英文名称英文同义词CAS号分子式分子量EINECS号相关类别Mol文件结构式

马来酸甲麦角新碱

马来酸甲麦角新碱;马来酸甲基麦角新碱;顺丁烯二酸甲基新麦角碱;马来酸甲麦角新碱杂质;为甲基麦角系统适用性 EP标准品;马来酸甲基麦角 EP标准品;马来酸甲酯麦角新碱;化合物 T21429

Methylergonovine maleate salt

erezingen;maleicacid,methylergonovine;METHYLERGOMETRINE MALEATE;METHYLERGONOVINE MALEATE;METHYLERGONOVINE MALEATE SALT;METHYLERGONOVINE MALEIC ACID SALT;9,10-DIDEHYDRO-N-[(S)-1-(HYDROXYMETHYL)PROPYL]-6-METHYLERGOLINE-8BETA-CARBOXAMIDE MALEATE SALT;[8B(S)]-9,10-DIDEHYDRO-N-[1-(HYDROXYMETHYL)PROPYL]-6-METHYLERGOLINE-8-CARBOXAMIDE MALEATE

57432-61-8

C24H29N3O6

455.51

260-734-4

医药原料;原料;METHERGINE;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals

57432-61-8.mol

马来酸甲麦角新碱 性质

熔点沸点密度折射率储存条件溶解度形态颜色水溶解性

1720C (dec)

561.98°C (rough estimate)

1.2744 (rough estimate)

1.6500 (estimate)

-20°C Freezer

在水中的溶解度25 mg/mL

固体

白色

Soluble to 25 mM in water

马来酸甲麦角新碱 用途与合成方法

生物活性Methylergometrine maleate (Methylergonovine maleate) 是一种麦角生物碱，是一种具有血管收缩和子宫收缩作用的 Methysergide 的活性代谢产物。Methylergometrine maleate 是一种有效的，选择性的，具有口服活性的 5-HT 受体拮抗剂，pA2 值为 9.6。Methylergometrine maleate 具有抗偏头痛和多巴胺能活性，可用于预防和控制产后出血。靶点

serotonin 9.6 nM (pA2)

体外研究

Both Methysergide and Methylergometrine displace the concentration-response curve of 5-HT to the right and depressed the maximum effect ; thus, both agents behaved as non-competitive antagonists of 5-HT. Methylergometrine is approximately 40-times more potent than Methysergide as an antagonist of the 5-HT-induced responses, since the calculated apparent pA2 values are 9.6 and 8.0, respectively.

体内研究

Methylergometrine is more potent than Methysergide as a vasoconstrictor on bovine middle cerebral artery and human coronary arteries, an effect on 5-HT1B receptors. Subacute oral administration would result in metabolism of Methysergide to Methylergometrine.