Cannabinoid derivative as a pharmaceutically activ

作者：Alan James Silcock | Antoine Millet | Karen Ka-Yen Tse | Paul Stuart Hinchliffe | Andrew Sharpe

发明人：Alan James Silcock | Antoine Millet | Karen Ka-Yen Tse | Paul Stuart Hinchliffe | Andrew Sharpe

所有人：GW Research Limited 年：2022,

语种：英语

公开国家：GB 国家：英国

专利申请号：GB2019784-4 专利申请日期：2020-12-15

公开(公告)号：GB-2602019-A 公开日期：2022-06-22

分类号：C07D-231/12 国际主分类号：C07D-231/12 国际分类号：C07D-231/12 | A61K-31/415 | A61P-25/08

摘要：Abstract Title: Heterocyclic cannabidiol derivative (1R,2R)-5-methyl-4-(1-methyl-1H-pyrazol-4-yl)-2-(prop-1-en-2-yl)-1,2,3,4-tetrahydro-[1,1-biphenyl]-2,6-diolA compound of Formula I or a salt thereof:The compound of Formula I is for use as a medicament, for use in the treatment of epilepsy. A pharmaceutical composition comprising a compound of Formula I is also disclosed. The pharmaceutical composition may be a tablet, capsule, granule, powder for inhalation, sprinkle, oral solution or a suspension. The pharmaceutical composition may additionally comprise an excipient, disintegrant, lubricant, stabilizer, flavouring agent, antioxidant, diluent or another pharmaceutically effective compound. The compound of the invention is a cannabinoid derivative, an analogue of cannabidiol (CBD). The compound of the invention is (1’R,2’R)-5’-methyl-4-(1-methyl-1H-pyrazol-4-yl)-2’-(prop-1-en-2-yl)-1’,2’,3’,4’-tetrahydro-[1,1’-biphenyl]-2,6-diol. Also claimed is a process for the production of a compound of Formula I comprising coupling menthadienol with phloroglucinol, reacting the intermediate via triflation reaction to produce an aryl triflate intermediate, followed by subsequent steps to produce the compound of Formula I.