Tuftsin
性状用途生物活性靶点体外研究| Tuftsin |
| 吞噬刺激素;促吞噬素;增免疫苏精肽H-THR-LYS-PRO-ARG-OH;化合物TUFTSIN |
| TUFTSIN |
| TUFTSIN;TUFTSIN 2ACOH 4H2O;THR-LYS-PRO-ARG;THR-LYS-PRO-ARG 2ACOH 4H2O;Tuftsin hydrate acetate salt;L-Thr-L-Lys-L-Pro-L-Arg-OH;Taftsin;Tuftsin Tuftsin acetate salt hydrate |
| 9063-57-4 |
| C21H40N8O6 |
| 500.59 |
| 多肽;生化试剂;其他生化试剂;标准品;目录多肽;Peptide |
| 9063-57-4.mol |
Tuftsin 性质
| 1.48±0.1 g/cm3(Predicted) |
| −20°C |
| 固体 |
| 3.60±0.21(Predicted) |
| 白色至米白色 |
| Water : ≥ 160 mg/mL (319.62 mM) |
| H-Thr-Lys-Pro-Arg-OH |
Tuftsin 用途与合成方法
性状Tuftsin外观呈固体粉末状。用途Tuftsin 是一种免疫刺激剂，通过促进吞噬作用、抗原呈递和细胞迁移来诱导杀菌和杀肿瘤活性。生物活性Tuftsin 是一种四肽。Tuftsin是巨噬细胞/小胶质细胞激活剂。靶点|
Human Endogenous Metabolite
|
Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors.
参考质量标准外观:白色粉末纯度(HPLC) ≥98.0%醋酸根含量≤12.0%水分含量≤8.0%肽含量≥80.0%内毒素≤50EU/mg氨基酸组成分析≤±10%
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