苯妥英检测

苯妥英

简介适应症副作用生物活性靶点体外研究体内研究 用途与合成方法 MSDS 苯妥英价格(试剂级) 上下游产品信息 专题中文名称中文同义词英文名称英文同义词CAS号分子式分子量EINECS号相关类别Mol文件结构式

苯妥英

5,5-二苯基海因;5,5-二苯基乙内酰脲;苯妥英;5-二苯基海因;苯妥英标准溶液;5,5-二苯基乙内酰脲(苯妥英);苯妥英 溶液;5,5-二苯基海因 溶液

5,5-Diphenylhydantoin

4,5-Diphenyl-4-imidazoline-2-one;5,5-Diphenyltetrahydroglyoxalin-4-one;5,5-Diphenylhydantoin-2-13C, 3-15N;PHENYTOIN,USP;Dantinal;Dantoinal;Dantoinal klinos;Dantoinalklinos

57-41-0

C15H12N2O2

252.27

200-328-6

芳烃;小分子抑制剂;离子通道;膜转运;医药中间体;对照品;有机化工原料;医药原料;药物杂质及中间体;医药原料药;中药对照品;化工原料;原料药;API intermediate;Aromatics;Heterocycles;API's

57-41-0.mol

苯妥英 性质

熔点沸点密度折射率闪点储存条件溶解度酸度系数(pKa)形态颜色水溶解性MerckBRN稳定性InChIKeyCAS 数据库NIST化学物质信息(IARC)致癌物分类EPA化学物质信息

293-295 °C (lit.)

395.45°C (rough estimate)

1.1562 (rough estimate)

1.5906 (estimate)

11 °C

2-8°C

可溶于DMSO

pKa 8.43(H2O,t =25,I=0.025) (Uncertain)

粉末

白色到近乎白色

<0.01 g/100 mL at 19 ºC

14,7322

384532

稳定的。易燃。与强氧化剂、强碱不相容。

CXOFVDLJLONNDW-UHFFFAOYSA-N

57-41-0(CAS DataBase Reference)

5,5-Diphenylhydantoin(57-41-0)

2B (Vol. Sup 7, 66) 1996

Phenytoin (57-41-0)

苯妥英 用途与合成方法

简介

苯妥英是一种抗癫痫药，用于治疗多种癫痫发作。它也是一种Vaughan-WilliamsⅠB类抗心律失常药，但目前*少用于治疗心律失常。

适应症苯妥英是一种抗惊厥药物，其在治疗强直阵挛性发作及部分发作有治疗效果，但无法治疗失神性发作。苯妥英能借由口服或静脉注射给药，当癫痫重积状态发生时，可借由静脉注射给予苯妥英，相对的苯二氮䓬类则无法治疗该症状。该药也可治疗特定的心律不整及神经性疼痛。副作用

苯妥英常见副作用包含恶心、胃痛、缺乏食欲、肢体协调不良、毛发增长，以及牙龈增生。其他可能的严重副作用则包含嗜睡、自残、肝脏问题、骨髓抑制、低血压，以及毒性表皮溶解症。

生物活性Phenytoin (Diphenylhydantoin) 是一种失活的电压门控钠离子通道稳定剂。靶点

Target	Value
Sodium channel

体外研究

Phenytoin is an antiepileptic drug. It is useful to partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures. Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels. Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane potentials. When neurons are depolarized and the channels transition into the open and inactivated states, greater binding and block occur. The inhibitory potency is strongly use dependent, so that block accumulates with prolonged or repetitive activation, such as occurs during a seizure discharge. The blocking of sodium channels by phenytoin is of slow onset. The time course of fast sodium currents is therefore not altered in the presence of the drug and action potentials evoked by synaptic depolarizations of ordinary duration are not blocked. Thus phenytoin is able to selectively inhibit pathological hyperexcitability in epilepsy without unduly impairing ongoing activity. Phenytoin also blocks persistent sodium current and this may be of particular importance in seizure control. Phenytoin is a class 1b antiarrhythmic.

体内研究

Phenytoin (5,5-Diphenylhydantoin; 60 mg/kg; daily; 28 days ) reduces tumour growth in six week-old female Rag2 -/- Il2rg -/- mice with MDA-MB-231 cells.

用途 用作抗癫痫药、抗心律失常药