氨硫脲检测

氨硫脲

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 氨硫脲价格(试剂级) 上下游产品信息中文名称中文同义词英文名称英文同义词CAS号分子式分子量EINECS号相关类别Mol文件结构式

氨硫脲

氨硫脲 1G;结核安;4-乙酰氨基苯甲醛硫代卡巴棕;氨苯硫脲;结核胺;硫醋腙;硫脲胺;氨硫脲杂质

THIACETAZONE

4’-formyl-acetanilid4’-(thiosemicarbazone);4207 RP;4207rp;A 4081;Acetamide, N-(4-(((aminothiomethyl)hydrazono)methylene)phenyl)-;Acetamide, N-[4-[[(aminothioxomethyl)hydrazono]methyl]phenyl]-;Acetamide, N1-(4-{[2-(aminocarbothioyl)hydrazono]methyl}phenyl);Acetanilide, 4'-formyl-, 4'-(thiosemicarbazone)

104-06-3

C10H12N4OS

236.29

203-170-6

感受态;细胞-细胞系;化学试剂;Aromatic Aldehydes & Derivatives (substituted)

104-06-3.mol

氨硫脲 性质

熔点密度折射率储存条件溶解度形态酸度系数(pKa)颜色

225-230 °C

1.2752 (rough estimate)

1.6440 (estimate)

Store at -20°C

溶于二甲基亚砜

粉末晶体

11.35±0.70(Predicted)

白色至橙色再至绿色

氨硫脲 用途与合成方法

生物活性Thiacetazone (Thioacetazone) 是一种含硫脲的抗结核剂，也是一种具有口服活性抗生素。Thiacetazone 具有抗菌作用，可抑制结核分枝杆菌 H37Rv (Mycobacterium tuberculosis H37Rv) 的生长，其 MIC 值为 0.1 μg/mL。靶点

MIC: 0.1 μg/mL ( Mycobacterium tuberculosis H37Rv )

体外研究

Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl.

体内研究

The K m and V max values for the N-deacetylation of Thiacetazone are 0.57 mM and 0.123 nmol of p-aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat.

化学性质 淡黄色结晶或结晶性粉末。在225-230℃分解。溶于热醇，微溶于冷醇，*微溶于水，不溶于氯仿、乙醚，溶于氢氧化钾乙醇溶液。用途 该品能抑制结核菌、麻风菌，使菌体形态变化、颗粒消失、染色质改变。*早用于治疗麻风病，效果不如砜类，但对结核型麻风效果好。生产方法 由对乙酰氨基苯甲醛与硫氰酸肼在冰醋酸于104℃反应而得。该法收率95%。