METHOD OF TREATING MALIGNANT RHABDOID TUMOR OR SMALL CELL CANCER OF THE OVARY OF THE HYPERCALCEMIC TYPE

The disclosure provides a method of treating a malignant rhabdoid tumor in a subject in need thereof including administering to the subject a therapeutically-effective amount of an enhancer of a zeste homolog 2 (EZH2) inhibitor. In certain embodiments of this method the malignant rhabdoid tumor is small cell cancer of the ovary of the hypercalcemic type (SCCOHT) and the EZH2 inhibitor is tazemetostat (also known as Tazemetostat). See Fig. 18A.WO 2017/053930 PCT/US2016/053673 18/20 (D ~ 0 C 75 E ~LO 0 4' 0 a 0' Cf n wD tm 0 CN 0 1 r_ Q: 0 CDC Sn0 >n CD CD~ C) EE ~ 0sbi p olno' uO 4' 4' ' t. -T .J S 4' 4' 4 C' M' CM' E' EE 44' LO0 00 CDF 010 o~ E 0 C - LO~C E 4' E >' CD, C C) > CD CD C CD CDCo C5 C) C) CD C 0 0 0o 0 r 0 n 0 0 ww) owflOA jowni (C ww) UwflOA jowfl